a smartPAC
Contact Advanced Tissue

Scientists Explore How Neutrophils Aid Wound Healing

Scientists Explore How Neutrophils Aid Wound Healing

  by    0   2

Immune cells known as neutrophils aid in wound healing.

Researchers now have a better understanding of how these immune cells move throughout the body.

When it comes to dealing with wounds, your body has quite the amazing lineup of defense mechanisms. However, one especially noteworthy member of this frontline are neutrophils. This specialized immune cell travels into a wound site and releases enzymes to fight off infectious microorganisms, according to the U.S. National Library of Medicine.

But when they’re not busy saving the day and improving wound healing function, these cells just float aimlessly through the bloodstream. So, what causes these cells to transform into infection fighting machines? To solve the puzzle, a group of researchers from the National Institutes of Health, Shanghai’s Fudan University and the University of Illinois at Chicago joined forces to explore what really makes these neutrophils tick.

The mighty neutrophils

After exhaustive research, the joint team – who published their results in a recent edition of the journal Developmental Cell – found the secret to the neutrophils’ transformative capabilities: a specific receptor molecule. Namely, this is a molecule that is responsible for interacting with reactive oxygen species. Often referred to as just ROS, this unique chemical species contains oxygen and generally damage the structures of various molecules, according to Kimball’s Biology Pages.

Within the neutrophils there is a receptor called TRPM2, which acts as a kind of ROS sensor or guide. Whenever a neutrophil comes across some bacteria or other foreign body, it lets out a burst of ROS to destroy the invader. Then, thanks to the functions of TRPM2, the neutrophils enter a docile state until the next “attack” by outside particles.

In an accompanying press release, lead author Jingsong Xu explained just how dependent neutrophils are on these chemical reactions for basic movement.

“The neutrophil senses a dramatic increase in reactive oxygen species as it gets closer to the wound site, and this triggers the shutdown of the migration of the cell,” he said. “Once the neutrophil ceases moving, it just kills one bacteria or pathogen after another — and can concentrate on doing its job of cleaning up the site.”

Xu added that another key part of this process is chemical oxidization. Without it, the neutrophils would be on full alert at all times. Luckily, the TRPM2 is oxidized whenever the ROS is released.

As beneficial as this process is, Xu added that too many active neutrophils can damage tissue structures. That echoes a study released in mid-2015, in which the impediment of neutrophils improved wound healing in diabetic mice. All of this insight into neutrophils is vital, and helps scientists better understand the complexity of effective wound care.
For all your specialized wound care products, turn to Advanced Tissue. We deliver to both homes and long-term care facilities.

Download our FREE Wound Treatment Product Guide for more information on our wound care supplies.

Download Now

Related Posts

Wound Blush an Important Tool for Battling CLI

Wound blush an important tool for battling CLIJapanese doctors have made an important new discovery in treating CLI, which impacts human blood vessels. Peripheral artery disease is what happens when blood vessels in your limbs narrow, cutting off vital circulation. If left untreated, PAD can eventually turn into critical limb ischemia, or when arteries are blocked fully, leading to sores and ulcers.  According to […]


Healthy Cooking Tips to Use Every Day

Healthy cooking tips to use every dayEating more grains, like this barley soup, is one way to help ensure proper nutrients. In a recent post, we explored the importance of healthy cooking every day. Things like avoiding high-sodium food and controlling your intake of fatty foods can make a huge difference to your personal well-being. This is done not just by […]


Tips for Building a Better Relationship with Doctors

Tips for building a better relationship with doctorsIt’s essential to have a professional and enduring relationship with your physician. For some people, doctor’s visits only occur once a year for check-ups and the like. However, for a large percentage of Americans – especially those that cope with chronic wounds – doctor’s visits are a regular part of daily life. This is reflected in […]


3 Tips to Start a Walking Regimen

3 tips to start a walking regimenWalking is a quick and easy way to help maintain your health and wellbeing. These days, most people are aware of the importance of exercise for both your physical and mental well-being. However, because of certain constraints – like those related to an ongoing wound care regimen – exercises like biking or lifting weights at the gym […]


Doctors Find New Natural Way to Prevent Scars

Doctors find new natural way to prevent scarsThe process involves a previously unseen transformation of cells essential to the wound healing process. Scars are a particularly sore subject for most people. Not only are they aesthetically unpleasing, but some of them can prove painful. That’s why research into minimizing the appearance of scars continues to be a central priority of wound care-related […]


Leave a Reply

Your email address will not be published. Required fields are marked *

Back to Top